COLLOQUIUM 2026

Abstract

Programming matter at the molecular scale is a transformative frontier in science and engineering. Our research advances a vision to create programmable, bioinspired molecular systems that expand capabilities in medicine, materials science, and nanotechnology. Using nucleic acids as programmable building blocks, my laboratory engineers DNA- and RNA-based nanostructures that mimic and extend biological function for applications in adaptive materials and precision therapeutics. We define a new paradigm built on four core capabilities – Structure, Sense, Actuate, and Compute – to enable intelligent nanosystems capable of autonomous, context-dependent responses. This approach underpins programmable materials that adapt to environmental cues and programmable medicine in which therapeutic activity is dynamically regulated in real time. Guided by four interconnected pillars – Design, Assembly, Functionalization, and Interface – our work creates program molecular systems with broad translational potential.