Faculty

THONG Soo Ping, Patricia

PhD, National University of Singapore (1997)

Adjunct Associate Professor
Tel : (65) 6516 1246
Email : nmstsp@nccs.com.sg or phytsppb@nus.edu.sg

Current Research

Optical Imaging & Spectroscopy for Cancer Diagnosis

  • Fluorescence imaging, fluorescence endoscopy and optical spectroscopy for clinical cancer diagnosis and image-guided procedures.
  • Fluorescence confocal endomicroscopic imaging and its applications to cancer research.

Photodynamic Therapy (PDT) for Cancer Treatment

  • Clinical applications of PDT for treatment of cancer.
  • Investigating mechanisms underlying PDT-induced cell killing.
  • Monitoring tumour response to PDT using noninvasive spectroscopy.

Applications of Proton Microscopy to Biomedical Research

  • Applications of nuclear microscopy to cancer treatment research.
  • Investigating proton beam induced damage to cells, leading to clinical application of proton beam therapy for cancer.

Selected Publications

Optical Imaging & Spectroscopy for Cancer Diagnosis

  1. Thong PS, Olivo M, Chin WW, Bhuvaneswari R, Mancer K, Soo KC. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. Br J Cancer. 2009; 101(9):1580-4.

  2. Thong PS, Olivo M, Tandjung SS, Movania MM, Lin F, Qian K, Seah HS, Soo KC. Review of Confocal Fluorescence Endomicroscopy for Cancer Detection. IEEE J Sel Topics Quantum Electron. 2012; 18(4):1355-66.

  3. Thong PS, Tandjung SS, Movania MM, Chiew WM, Olivo M, Bhuvaneswari R, Seah HS, Lin F, Qian K, Soo KC. Toward real-time virtual biopsy of oral lesions using confocal laser endomicroscopy interfaced with embedded computing. J Biomed Opt. 2012; 17(5):056009.

Photodynamic Therapy (PDT) for Cancer Treatment

  1. Thong PS, Ong KW, Goh NS, Kho KW, Manivasager V, Bhuvaneswari R, Olivo M, Soo KC. Photodynamic-therapy-activated immune response against distant untreated tumours in recurrent angiosarcoma. Lancet Oncol. 2007; 8(10):950-2.

  2. Dong J, Toh HJ, Thong PS, Tee CS, Bi R, Soo KC, Lee K. Hemodynamic monitoring of Chlorin e6-mediated photodynamic therapy using diffuse optical measurements. J Photochem Photobiol B. 2014; 140:163-72.

  3. Bhuvaneswari R, Ng QF, Thong PS, Soo KC. Nimotuzumab increases the anti-tumor effect of photodynamic therapy in an oral tumor model. Oncotarget. 2015; 6(15):13487-505.

Applications of Proton Microscopy to Biomedical Research

  1. Thong PS, Watt F, Ren MQ, Soo KC and Olivo M. Investigating the role of calcium and biological trace elements in hypericin photodynamic therapy induced tumor cell death using nuclear microscopy. Nucl Instrum Meth B. 2005; 231(1-4):315-20.

Affiliations & Links