Next Seminar


Rapid and Label-free Magnetic Resonance based Molecular Phenotyping of Oxidative Stress of Diabetes Mellitus

Speaker:  Peng Weng Kung (Nanyang Technological University)
Date:  Wed, 8-Feb-2017, 11:00-12:00
Venue:  Physics Conference Room (S11-02-07)



Abstract

Diabetes mellitus (DM) is one of the fastest growing health burdens that is projected to affect 592 million people worldwide by 2035 [1]. In this talk, a new paradigm of molecular phenotyping using the fundamental of spin physics for clinical diabetes care and management, will be introduced. Specifically, we aim to establish high throughput oxidative stress and metabolic phenotyping platform for DM. We have recently shown that various pathological states (e.g., oxidative stress of diabetes mellitus [2], malaria infection [3,4], and blood oxidation/oxygenation level [5,6]) can be rapidly captured (< 5 minutes) by mapping out the redox properties of blood (< 10 µL) using inexpensive, home-built, microscale magnetic resonance (MR) technology. A range of microscale MR technology (relaxometry, spectroscopy, imaging) developed in the pipeline will be used as the platform in translating a new class of functional biomarkers for DM medical research and clinical practices. In addition, the speaker will discuss briefly the newly developed ultrafast multidimensional relaxographic imaging [7] for next generation of rapid and label-free molecular phenotyping. We demonstrate its clinical utilities in sub-phenotyping the hemoglobinopathies (e.g., thalassemia), assessment of glucose toxicity in pancreatic islets and sub-stratification of endometriosis disease.

References
1. Mutlu, F., et al. Projection of Diabetes Burden through 2025 and Contributing Risk Factors of Changing Disease Prevalence: An Emerging Public Health Problem. J Diabetes Metab 5, 2 (2014).
2. Peng, W.K., Chen, L., Loh, T.P. Molecular Phenotyping of Oxidative Stress in Diabetes Mellitus with micro Magnetic Resonance Relaxometry. Nature Molecular Phenomics (resubmission).
3. Peng, W.K., et al. Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis. Nature Medicine 20, 1069-1073 (2014).
4. Kong, T.F., Peng, W.K., Han, W.H., M, Preiser, P.P., Nguyen, N.-T., & Han, J. Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection. Scientific Reports 5, 11425 (2015).
5. Kong, T.F., Peng, W.K., Luong, T.D., Nguyen, N.-T. & Han, J. Adhesive-based liquid metal radio frequency microcoil for magnetic resonance relaxometry measurement. Lab on a Chip 12, 287-294 (2012).
6. Peng, W.K., Chen, L. & Han, J. Development of miniaturized, portable magnetic resonance relaxometry system for point-of- care medical diagnosis. Review of Scientific Instruments 83, 095115 (2012).
7. Peng, W.K., et al. Multidimensional T1-T2 Correlational Spectroscopy for Rapid and Label-free Molecular Phenotyping of Blood, Nature Communication (submission).

About the Physics Seminar

The seminar is regularly held on Wednesday, 11:00-12:00 in S11-02-07 (New Physics Conference Room).
Exceptions will be noted above and in the announcements.

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